I use both 20lb and 40lb Seaguar Blue Label or Premier LEADER line for pike. I use Gamakatsu inline straight shank octopus circle hooks in #2 and 1/0. I could be talked into a 2/0 if I was using >8in baits. The lighter the line and smaller the hook, the more natural your presentation will be.
I have had one bite off in three years of using fluorocarbon exclusively, and that was a hammer handle at the hole that wanted to run, and I didn't let it. Play them out right, check your leader after every HOOKSET you make, and the amount of bite offs you incur should be minimal.