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They are more money up front, but a truck with a diesel is the way to go, IMO. Keep the oil changed and they go for about forever. There is no reason not to expect 300000 to 400000 miles with proper maintenance. No plugs and wires to change. The down side is if you do have problems, they will be a lot more money to fix.
What are you looking to replace your truck with? I'd like another truck, but the gas is killing me! It's tough to throw a deer into a minivan though.